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Inhibition of STEAP1 ameliorates inflammation and ferroptosis of acute lung injury caused by sepsis in LPS-induced human pulmonary microvascular endothelial cells

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In this paper, we present a new integrated model for hepatic glutathione metabolism including one-carbon metabolism and use it to investigate how the activation of certain enzymes by estradiol in one-carbon metabolism and glutathione metabolism leads to dramatic changes in reaction velocities and metabolite concentrations, including GSH and the GSH synthesis rate